Methotrexate is a medication used to treat a variety of conditions, including rheumatoid arthritis, psoriasis, and leukemia. Some people who take methotrexate experience troublesome side effects, including brain fog.
Brain fog is a term used to describe feelings of confusion and lack of focus. It can be very disruptive and frustrating. Some people who take methotrexate say that the drug causes them to experience brain fog.
It's unclear whether or not methotrexate actually causes brain fog. It's possible that some people who take the drug simply attribute their brain fog to the medication, when in fact it was already present before they started taking methotrexate.
If you are concerned about experiencing brain fog while taking methotrexate, talk to your doctor. He or she may be able to recommend strategies for avoiding or minimizing this side effect.